Rheumatology Medical News about patient reported outcomes;systemic lupus erythematosus

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The minimally important difference for patient reported outcomes in systemic lupus erythematosus including the HAQ-DI, pain, fatigue, and SF-36
Journal of Rheumatology, 09/15/09

Colangelo KJ et al. –The MID in patients with SLE may be different bidirectionally depending on the measured outcome. The mean change observed for those reporting better than worse outcome in pain and fatigue was greater for better versus worst, in contrast to the HAQ, where the mean change was greater for worsening.

Methods

Patients with SLE had 2 consecutive clinic visits
Completed a HAQ-DI and a pain, fatigue, and sleep visual analog scale (VAS)
Completed overall health status question: “How would you describe your overall status since your last visit?”: much better, better, the same, worse, or much worse were included
Those self-rated as better or worse were considered the “minimally changed” subgroups

Results

202 patients (94% women, mean age 50 yrs, mean disease duration 10 yr)
MID for better and worse on a VAS (0-100) were: pain (–15.8, 8.5), fatigue (–13.9, 9.1), and sleep problems (–8.6, 7.6)
MID for HAQ-DI (scale 0 to 3) was –0.08 (better) and 0.14 (worse)
MID for SF-36 was 2.1 (better) and –2.2 (worse) for the PCS and 2.4 (better) and –1.2 (worse) in MCS

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