Rheumatology Medical News about rheumatoid arthritis;discontinuation ;TNF blocking agent

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The reason for discontinuation of the first tumor necrosis factor (tnf) blocking agent does not influence the effect of a second tnf blocking agent in patients with rheumatoid arthritis
Journal of Rheumatology, 09/11/09

Blom M et al. – The results of our observational study suggest that a second TNF blocking agent may be effective after failure of the first, regardless of the reason for discontinuation of the first TNF blocking agent.

Methods

Data were used from 2 Dutch registries including patients with rheumatoid arthritis (RA) treated with TNF blocking agents
Patients were divided into 3 groups based on reason for discontinuation of the first: nonresponse, loss of response, or adverse events

Results

In total, 49 patients who failed due to nonresponse, 75 due to loss of response, and 73 due to adverse events were included
At 6 mos, the change of DAS28 score from baseline did not differ significantly between the groups (–0.6 to –1.3) and similar good and moderate response rates were found (12% to 18%, and 34% to 55%, respectively)

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