Rheumatology Medical News about knee/hip osteoarthritis;total joint replacement

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OARSI/OMERACT criteria of being considered a candidate for total joint replacement in knee/hip osteoarthritis as an endpoint in clinical trials evaluating potential disease modifying osteoarthritic drugs
Journal of Rheumatology, 09/14/09

DOUGADOS M et al. – The goal of the ongoing OARSI/OMERACT initiative is to propose criteria for being considered a candidate for total joint replacement to be used as an endpoint in clinical trials evaluating potential DMOAD.

Methods

OARSI/OMERACT task force conducted study in 3 steps
3 main domains — pain, function, structure — revisited
“Non-acceptable state” and a “relevant” progression for structure defined
Set of criteria proposed combining information from 3 domains

Results

Questionnaire was elaborated for the domains “pain” and “function”
Evaluation of different databases concluded that domain “structure” should be evaluated by radiological joint space width in mm
Unacceptable radiographic progression defined as change in joint space width over measurement error.
International, cross-sectional study proposing a definition of a “nonacceptable symptom state”

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