Rheumatology Medical News about fibromyalgia; disordered sleep

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Objective measures of disordered sleep in fibromyalgia
Journal of Rheumatology, 09/09/09

Chervin RD et al. – Standard measures of sleep, a gold–standard measure of sleepiness, quantified alpha–delta EEG power, auditory arousal thresholds, and urinary free cortisol largely failed to distinguish FM and control subjects. However, HRV analyses showed more promise, as they suggested both increased sympathetic activity and decreased complexity of autonomic nervous system function in FM.

Methods

15 women with FM and 15 age– and gender–matched controls underwent 3 nights of polysomnography; Multiple Sleep Latency Tests to assess sleepiness; testing of auditory arousal thresholds during non–REM stage 2 and stage 4 sleep; overnight assessment of urinary free cortisol; and analysis of 24–hour heart rate variability

Results

On the second night of polysomnography, women with FM in comparison to controls showed more stage shifts (p = 0.04) but did not differ significantly on any other standard polysomnographic measure or on the Multiple Sleep Latency Tests
Alpha EEG power during deep non–REM sleep, alone or as a proportion of alpha power during remaining sleep stages, also failed to distinguish the groups, as did auditory arousal thresholds
Urinary free cortisol did not differ between FM and control subjects in a consistent manner; however, decreased short–term heart rate variability (HRV) and especially ratio–based HRV among FM subjects suggested diminished parasympathetic and increased sympathetic activity, respectively

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