Rheumatology Medical News about interleukin 1 gene cluster polymorphisms;bilateral distal interphalangeal osteoarthritis

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Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis
Journal of Rheumatology, 09/09/09

Solovieva S et al. – A role of IL1 gene cluster polymorphisms in the etiology of OA is suggested and some of these may predispose DIP joints to the effects of mechanical overload.

Methods

Radiographs of both hands of 295 dentists and 248 teachers were examined and classified for the presence of OA using reference images
Bilateral DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least 1 symmetrical pair of the DIP joints
We genotyped 10 single-nucleotide polymorphisms (SNP) in the IL1R1, IL1RL2, IL1A, IL1B, and IL1RN genes using polymerase chain reaction-based methods
Haplotypes were statistically reconstructed using the PHASE program

Results

Two IL1B SNP (rs1143634 and rs1143633) were associated with bilateral DIP OA
The carriers of the IL1B rs1143634 minor allele had an increased OA risk compared to the noncarriers
The distribution of the IL1B rs1143633 genotype fit a recessive mode of inheritance
Two IL1B-IL1RN extended haplotype alleles (211-1 and 121-1) were associated with bilateral DIP OA
An interaction between the IL1B rs1143634 and the IL1R1-IL1RL2 and IL1B-IL1RN extended haplotypes and occupation (increased risk of OA among dentists only) was observed

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