Rheumatology Medical News about severe inflammatory polyarthritis;Sjogrens syndrome

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Association of severe inflammatory polyarthritis in primary Sjogren's syndrome: Clinical, serologic, and HLA analysis
Journal of Rheumatology, 09/10/09

Mohammed K et al. – Severe arthritis with features resembling rheumatoid arthritis including erosive disease can occur in primary SS, particularly among those with anti-citrulline antibodies and the SE.

Methods

Case-control study comparing 35 patients with primary SS
17 patients with inflammatory arthritis
18 patients without arthritis

Results

All patients had anti-Ro/SSA autoantibodies
Most had anti-La/SSB autoantibodies
High percentage had anti-citrullinated peptide antibodies absent in those without inflammatory arthritis
Most with anti-citrulline antibodies expressed MHC class II molecules with the shared epitope (SE).
Presence of DRB1*0301 linked to the expression of anti-Ro/SSA autoantibodies did not influence level or frequency of anti-citrulline antibodies

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Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
Critical Care, 11/09/09 Relevance Score: 67%

Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring Recommendations
Clinical Gastroenterology and Hepatology, 11/04/09 Relevance Score: 67%

Early treatment with and time on first Disease Modifying Anti-Rheumatic Drug predicts long-term function in patients with inflammatory polyarthritis
Annals of Rheumatic Diseases, 11/11/09 Relevance Score: 66%

Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
Journal of Clinical Anesthesia, 10/19/09 Relevance Score: 66%

Association of functional outcome with both personal- and area-level socioeconomic inequalities in patients with inflammatory polyarthritis
Arthritis Care and Research, 10/07/09 Relevance Score: 65%