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See Latest ArticlesComparison of screening procedures for Mycobacterium tuberculosis infection among patients with inflammatory diseases
Journal of Rheumatology, 09/09/09
Soborg B et al. – The study documented a high degree of discordant positive QFT and TST results. A positive QFT was more closely associated with risk factors for M. tuberculosis infection than the TST. The use of corticosteroids affected test outcome by increasing the risk for an inconclusive QFT result and decreasing the risk for a positive TST result.
Methods- The interferon-? response to in vitro stimulation of M. tuberculosis-specific antigens was measured with QFT and results were compared with TST
- QFT and TST results were available for 294/302 and 241/302 patients, respectively; 234 had results from both tests
- 21 (7%) tested positive with QFT and 45 (19%) with TST
- A positive QFT was associated with risk factors for M. tuberculosis infection, i.e., birth or upbringing in a TB-endemic area [risk ratio (RR) = 7.8), previous TB treatment (RR 4.7), and any latent TB infection risk factor (RR 4.7)
- Treatment with corticosteroids increased the risk for an inconclusive QFT result (RR 4.2) and decreased the risk for a positive TST result (RR 0.4)
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