Rheumatology Medical News about rheumatoid arthritis;STAT4 gene

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A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor
Rheumatology, 09/10/09

Li H et al. – The STAT4 RA-susceptibility haplotype identified in other previously reported populations has not been replicated in the Han Chinese population. It is associated only with the presence of RF in the Han Chinese population with RA disease.

Methods

750 RA patients and individually matched 750 healthy controls
Genotyped for single nucleotide polymorphism , rs11889341, in STAT4
Association analyses performed on whole data set and on sex subsets
Significant relationships determined between clinical variables and rs11889341

Results

No evidence of a significant association between rs11889341 and RA
Heterozygous CT genotype was associated with RA in female group
No association found in male group and in any subsets of RA based on sex, RF and anti-cyclic citrullinated peptide (anti-CCP) antibody
In the Han Chinese population with RA disease a significantly decreased frequency of the minor T allele and TT genotype in the RF-positive subgroup compared with RF-negative subgroup was observed

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