Rheumatology Medical News about rheumatoid arthritis;development of gastric mucosal lesions;long-term nonsteroidal anti-inflammatory drug therapy;efficacy of famotidine

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Risk factors for the development of gastric mucosal lesions in rheumatoid arthritis patients receiving long-term nonsteroidal anti-inflammatory drug therapy and the efficacy of famotidine obtained from the FORCE study
Modern Rheumatology, 09/09/09

Kobata Y et al. – RA patients treated for long periods with NSAIDs for RA symptoms should be controlled with DMARDs, without consideration of increased doses of steroids, in terms of risk for NSAID-induced gastric mucosal injury. Simultaneously, concomitant use of histamine-2 receptor antagonists (H2RA) such as famotidine should be considered.

Methods

Upper gastrointestinal endoscopy was performed on 100 RA patients treated with NSAIDs

Results

Gastric mucosal injury was detected in 62 of 100 patients, and eight of these patients had ulcers
Previous history of ulcers, lifestyle, NSAID dosage, and body mass index were associated with the development of gastric mucosal injury, and the use of diclofenac and steroid dose were associated with the development of ulcers
Disease-modifying antirheumatic drugs (DMARDs) did not appear to influence the risk of NSAID-induced gastric mucosal injury

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