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See Latest ArticlesA CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-CCP negative rheumatoid arthritis
Annals of Rheumatic Diseases, 09/08/09
Skinningsrud B et al. – This is the first report of a CLEC16A association with JIA, and a split of the RA association according to anti-CCP status.
Methods- Three SNPs were genotyped in patients with RA (n=809), JIA (n=509), T1D (n=1211) and AD (n=414), and in healthy controls (n=2149)
- All diseases were associated with CLEC16A, but with different SNPs
- The intron 22 SNP, rs6498169, was associated with RA (p=0.006) and JIA (p=0.016), and the intron 19 SNPs, rs12708716/rs12917716, with T1D (p=1x10-5) and AD (p=2x10-4)
- The RA association was confined to the anti-CCP negative subgroup (p=2x10-4)
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