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See Latest ArticlesGlycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener’s granulomatosis
Clinical and Experimental Rheumatology Online, 09/17/09
Finkielman JD et al. – The glycosylation status of autoantigens appears to be crucial for the pathogenesis of some autoimmune diseases, since carbohydrates play a crucial role in the distinction of self from non–self. Proteinase 3 (PR3), the main target antigen for anti–neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener’s granulomatosis (WG), contains two Asn–linked glycosylation sites. The glycosylation status of PR3 has no impact on its recognition by ANCA in WG.
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