Rheumatology Medical News about myeloperoxidase-antineutrophil cytoplasmic autoantibodies;small vessel vasculitis

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Two types of myeloperoxidase-antineutrophil cytoplasmic autoantibodies with a high affinity and a low affinity in small vessel vasculitis
Clinical and Experimental Rheumatology Online, 09/08/09

Yoshida M et al. – The affinity of MPO-ANCA from patients with MPO-ANCA-associated vasculitides were largely distinguished into a high and a low affinity, irrespective of the level of MPO-ANCA titers, and may be helpful for assessment of vasculitis activity affecting mainly the kidney and the lung.

Methods

Blood samples were collected from 27 newly diagnosed or relapsed patients with MPO-ANCA-associated vasculitides
The MPO-ANCA titer was determined by a direct enzyme-linked immunosorbent assay (ELISA) using homogeneously purified human MPO of leukocytes

Results

The MPO-ANCA affinity of 27 sera from 27 patients could be classified into a high-affinity type (14 sera) and a low-affinity type (13 sera); the mean values for IC50 in the two types were 0.15±0.06 µg/ml and 0.54±0.15 µg/ml, and the difference was statistically significant
Between the two groups of patients divided by the affinity, there were differences in the BVAS and CRP
The affinity remained steady from the disease onset to remission or relapse

<< Previous
Impact of cardiac magnetic resonance imaging for assessment of...

Next >>
Interleukin-12 gene polymorphisim in patients with giant cell...