Rheumatology Medical News about microscopic polyangiitis;Wegener's granulomatosis;CD57;CD8+ T lymphocytes

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Expression of CD57 on CD8+ T lymphocytes of patients with Wegener’s granulomatosis and microscopic polyangiitis: evidence for continuous activation of CD8+ cells
Clinical and Experimental Rheumatology Online, 09/08/09

Iking-Konert1 C et al. – In patients with WG and MPA a population of CD8+/ CD57+ expand, identifying terminally differentiated CD8+ cells. The prevalence of CD57+ cells was related to the course of disease. The data support the hypothesis that CD8+ T cells are activated in the context of primary vasculitides.

Methods

Receptor expression of CD57 was measured in CD8+ T cells of patients with active disease (n=5) by cytofluorometry and compared with expression in patients in remission (n=80) and in age-matched healthy donors (n=34)

Results

CD8+CD57+ were detected in patients with WG and MPA and in healthy donors as well and increased considerably with age
Compared to age-matched healthy donors, the prevalence of CD8+CD57+ was increased in the younger patients (up to 40 y)
In most patients a high percentage of CD8+CD57+ coincided with severe disease and multiple organ involvement, while low CD8+CD57+ percentage was seen in patients with limited disease or in patients in complete remission
In patients with smoldering disease, the percentage of CD8+CD57+ increased with time
High numbers of CD8+CD57+ correlated with low CD4:CD8 ratio

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