Rheumatology Medical News about elderly-onset rheumatoid arthritis;interleukin-12 gene polymorphism;giant cell atrteritis;polymyalgia rheumatica

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Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica, and elderly-onset rheumatoid arthritis
Clinical and Experimental Rheumatology Online, 09/08/09

Alvarez-Rodriguez L et al. – The IL-12 (-1188 A/C 3´UTR) gene polymorphism is not associated with disease susceptibility or severity in three age-related chronic inflammatory syndromes. The production of IL-12 p70 is dependent on the genetic background in HC, although in patients such association may be biased by other unknown factors.

Methods

The genotypes at -1188 in the 3´UTR of the IL-12 promoter by PCR-RFLP in 68 GCA, 138 PMR, and 72 EORA patients were analyzed, as well as in 465 healthy controls (HC). IL-12p70 levels in culture supernatants after stimulation with PMA+Ionomycin was assessed by ELISA

Results

All groups were in Hardy-Weinberg equilibrium
Allelic and genomic distributions werenot significantly different among the study groups
None of the genetic variants was associated with disease severity
Although the differences were not statistically significant, HC genotypes were associated with distinct IL-12 p70 production

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