Rheumatology Journals

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Marinou I et al. – These data suggest a role for genetically determined lower sIL–6R levels as being a risk factor for RA. The pro–inflammatory role of the IL–6 system in established RA has been highlighted by the used of anti–sIL–6R antibodies. The data, however, suggest a protective effect of IL–6 on the risk of developing RA.


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