Rheumatology Medical News about hypothalamic-pituitary-adrenal stress axis;susceptibility to musculoskeletal pain

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Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: Results from the EPIFUND study
Annals of Rheumatic Diseases, 09/04/09

Holliday KL et al. – Genetic variation in HPA axis genes was associated with musculoskeletal pain; however, some of the associations were explained by co-morbidities.

Methods

Pain and co-morbidity data was collected at 3 time-points in a prospective population-based cohort study
Pair-wise tagging SNPs were selected and genotyped for 7 genes
Genetic association analysis was carried out using zero-inflated negative binomial regression to test for association between SNPs and the maximum number of pain sites across the 3 time-points in subjects reporting pain
SNPs were also tested for association with chronic widespread pain (CWP)

Results

Seventy-five SNPs were successfully genotyped in 994 subjects including 164 cases with persistent CWP and 172 pain-free controls
Multiple SNPs in SERPINA6 were associated with the maximum number of pain sites, e.g., each copy of the T allele of rs941601 was associated with having 16% more pain sites compared to subjects with the CC genotype
SERPINA6 SNPs were also associated with CWP
Significant associations between the maximum number of pain sites and SNPs in CRHBP and POMC were also observed and a SNP in MC2R was also associated with CWP
Associations between SNPs and co-morbidity of poor sleep quality and depression explained some of the associations observed

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Stress Induced Hypothalamus-Pituitary-Adrenal Axis Responses and Disturbances in Psychological Profiles in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
The Journal of Urology, 10/14/09 Relevance Score: 67%

HPA axis response to psychological stress and treatment retention in residential substance abuse treatment: A prospective study
Drug and Alcohol Dependence, 10/23/09 Relevance Score: 66%

Race and Unhealthy Behaviors: Chronic Stress, the HPA Axis, and Physical and Mental Health Disparities Over the Life Course
American Journal of Public Health, 10/30/09 Relevance Score: 64%

Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts
Biological Psychiatry, 10/23/09 Relevance Score: 64%

Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy
Journal of Clinical Endocrinology and Metabolism, 10/15/09 Relevance Score: 64%