Rheumatology Medical News about arthritic joint;oxidative damage;synovial tissue

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Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint
Annals of Rheumatic Diseases, 09/04/09

Biniecka M et al. – Lipid peroxidation is associated with low oxygen tension in vivo, with disease activity and angiogenic marker expression in inflammatory arthritis.

Methods

Oxygen levels in synovial tissue were assessed using an oxygen/temperature probe
Nuclear and cytoplasmic 8-oxo-dG and 4-HNE were assessed in synovial tissue from 23 patients using immunohistochemistry
8-oxo-dG and 4-HNE levels in serum and synovial fluid were determined using 8-oxo-dG and Hexanoyl-Lys (HEL) adduct ELISA’s respectively
Serum VEGF and Ang2 were also measured by ELISA

Results

The median pO2 level in synovial tissue was profoundly hypoxic at 19.35mmHg (2.5%)
Nuclear 8-oxo-dG was significantly higher than nuclear 4-HNE levels in lining and sublining layers
Cytoplasmic 4-HNE levels were higher than cytoplasmic 8-oxo-dG in both cell layers
Reduced in vivo oxygen tension correlated with high lipid peroxidation in synovial fluid and tissue
Serum VEGF positively correlated with cytoplasmic 4-HNE expression and intensity in the lining layer
Serum Ang2 positively correlated with nuclear 4-HNE expression and intensity in both cell layers
DAS28-CRP correlated with nuclear 4-HNE expression in sublining layer and DAS28-ESR correlated with nuclear 4-HNE expression in both cell layers

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