Rheumatology Medical News about soy; hip fracture risk

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Gender-specific Associations Between Soy and Risk of Hip Fracture in the Singapore Chinese Health Study
American Journal of Epidemiology, 09/01/09

Koh W–P et al. – For both genders, hip fracture risk was positively associated with cigarette smoking and was inversely associated with body mass index. There was a statistically significant association of tofu equivalents, soy protein, and isoflavones with hip fracture risk among women but not among men. Compared with women in the lowest quartile of intakes for tofu equivalents (<49.4 g/day), soy protein (<2.7 g/day), and isoflavones (<5.8 mg/1,000 kcal/day), those in the second–fourth quartiles exhibited 21%–36% reductions in risk. Risk levels were comparable across the second, third, and fourth quartiles of soy intake categories.

Exclusive Author Commentary
Woon-Puay Koh, 09/01/09

In this paper, we report a novel finding that dietary soy protects against hip fracture in women but not in men. A biologically plausible explanation for this observation has been proposed and warrants further investigation. We also show that the reduction in risk could be observed at a level of moderate intake that should be achievable in most populations. Although recent clinical studies on the effect of soy on bone mineral density have produced mixed results, we hope that evidence from our observational study will continue to stimulate interest and further studies in this area.

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