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See Latest ArticlesAdiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis
Arthritis Care and Research , 09/02/09
Giles JT et al. – Adiponectin may represent a mechanistic link between low adiposity and increased radiographic damage in RA.
Methods- Patients with RA underwent total-body dual x-ray absorptiometry for measurement of total and regional body fat and lean mass, abdominal computed tomography for measurement of visceral fat area, and radiographs of the hands and feet scored according to the modified Sharp/van der Heijde (SHS) method
- Serum levels of adipokines were measured and cross-sectional associations with radiographic damage were explored, adjusting for pertinent confounders
- Among the 197 patients studied, adiponectin demonstrated a strong association with radiographic damage
- Adiponectin independently accounted for 6.1% of the explainable variability in SHS score, a proportion comparable with rheumatoid factor, and greater than HLA-DRB1 shared epitope alleles or C-reactive protein levels
- Resistin and leptin were not associated with radiographic damage
- The association of adiponectin with radiographic damage was stronger in patients with longer disease duration
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Today in Rheumatoid Arthritis...keeping you current
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