Rheumatology Medical News about painful contralateral knees;radiographic joint space narrowing

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Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the osteoarthritis initiative
Arthritis Care and Research , 09/02/09

Eckstein F et al. – Knees with advanced mJSN displayed greater cartilage loss than contralateral knees with less mJSN. These data suggest that radiography can be used to stratify fast structural progressors, and that MRI cartilage thickness loss is more pronounced at advanced radiographic disease stage.

Methods

80 patients with exhibition of bilateral pain, body mass index >25 (kg/m2), mJSN in 1 knee, no or less mJSN in the contralateral knee, and no lateral JSN in both knees
Medial tibial and femoral cartilage morphology was analyzed from the baseline and the 1-year followup MRI of both knees by experienced readers blinded to the time point and mJSN status

Results

Knees with more radiographic mJSN displayed greater medial cartilage loss (-80 um) assessed by MRI than contralateral knees with less mJSN (-57 um)
The difference reached statistical significance in participants with an mJSN grade of 2 or 3, but not in participants with an mJSN grade of 1
In knees with more mJSN, cartilage loss increased with higher grades of mJSN
Knees with an mJSN grade of 2 or 3 displayed greater cartilage loss in the weight-bearing medial femur than in the posterior femur or in the medial tibia

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