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Frequency and determinants of flare and persistently active disease in systemic lupus erythematosus
Arthritis Care and Research , 08/31/09
Nikpour M et al. – Persistent activity is a common disease state in SLE and should be an outcome variable in SLE clinical trials.
Methods- Prospective study
- 1/3 of patients had ≥ 1 flare in any given year
- 1/2 had persistently active disease (PAD) in any given year
- Nearly 60% of patients had episodes of flare or PAD per year
- 25% of patients had PAD without achieving the definition of flare
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