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See Latest ArticlesRisk factors and impact of recurrent lupus nephritis in patients with systemic lupus erythematosus undergoing renal transplantation: Data from a single US institution
Arthritis & Rheumatism, 09/01/09
Burgos PI et al. – African American ethnicity was independently associated with recurrent lupus nephritis. Allograft loss was associated with chronic transplant rejection and recurrence of lupus nephritis. Recurrent lupus nephritis is infrequent and relatively benign, without influence on a patient's survival.
Methods- The archival records of all kidney transplant recipients with a prior diagnosis of SLE (according to the American College of Rheumatology criteria) from June 1977 to June 2007 were reviewed
- Two hundred twenty of nearly 7,000 renal transplantations were performed in 202 SLE patients during the 30-year interval
- Recurrent lupus nephritis was noted in 20 patients (11%), allograft loss in 69 patients (39%), and death in 36 patients (20%).
- African American ethnicity was found to be associated with a shorter time-to-event for recurrent lupus nephritis
- Recurrent lupus nephritis and chronic rejection of the kidney transplant were found to be risk factors for allograft loss
- In patients with recurrent lupus nephritis, the lesion in the engrafted kidney was predominantly mesangial, compared with a predominance of proliferative or membranous lesions in the native kidneys
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