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ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala271
Arthritis & Rheumatism, 09/01/09
Zack MD et al. – The results of this study identify ADAM–8 as a fibronectinase in human OA chondrocytes. Because ADAM–8 is capable of producing the fibronectin neoepitopes VRAA271 and 272VYQP in human OA cartilage, this enzyme may be an important mediator of cartilage catabolism.
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Today in Osteoarthritis...keeping you current
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Osteoarthritis: A review of treatment options
Geriatrics, 10/21/09
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Cochrane Reviews, 10/23/09
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