Rheumatology Medical News about interleukin-7

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Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
Arthritis & Rheumatism, 09/02/09

Hartgring SAY et al. – The data suggest that enhanced expression of IL–7Ralpha and IL–7 in RA patients contributes significantly to the joint inflammation by activating T cells, B cells, and macrophages. The inhibition of IL–7Ralpha–mediated immune activation by soluble hIL–7R further indicates an important role of IL–7Ralpha in inflammatory responses in RA, suggesting IL–7Ralpha as a therapeutic target for immunotherapy in RA.

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Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells
Genes and Immunity, 10/26/09 Relevance Score: 80%