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See Latest ArticlesTRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
Arthritis & Rheumatism, 08/31/09
Han T-U et al. – Within and around TRAF1, excluding PHF19 and C%, SNPs highly correlated with rs7021206, but not those correlated with rs3761847, are associated with RA in both Asians and Caucasians.
Methods- 1316 unrelated RA patients and 1006 controls were genotyped for 12 SNPs identified in genome-wide scans and for 12 additional tag SNPs in IL2RB, OLIG3-TNFAIP3, PTNPN22, and TRAF1-C5
- None of the SNPs tested was associated with RA susceptibility, except rs7021206 in TRAF1 intron 3, and among the SNPs previously reported, rs6457617 in HLA
- The association of rs7021206 was positive in patients who were seropositive for RF or for anti-CCP autoantibodies
- RA susceptibility was localized to an extended haplotype marked by rs7021206 rather than rs3761847 and SNPs highly correlated with rs7021206 extended from rs1953126 in the PHF10-TRAF1 intergenic region to rs2900180 in the TRAF1-C5 intergenic region, spanning 66 kb
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