Rheumatology Medical News about pro-inflammatory cytokines;TREM-1 expression;rheumatoid arthritis

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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines
Rheumatology, 08/28/09

AKuai J et al. – The presence of high levels of functionally active TREM-1 in RA synovium may contribute to the development or maintenance of RA or both.

Methods

24 RA synovial samples were analysed by gene expression oligonucleotide microarrays
Expression of TREM-1 mRNA in murine CIA paws were determined by qPCR
TREM-1 protein expression was detected by IHC in 5 RA synovial samples and 2 OA synovial samples
TREM-1-positive cells from 5 RA synovialo tissues were analysed by FACS staining
Activation of TREM-1 was tested in 5 RA synovial samples
Soluble TREM-1 was measured in serum from 32 RA patients

Results

Expression of TREM-1 mRNA increased 6.5-fold in RA synovial samples, whereas it increased 132-fold in CIA paws
Increased numbers of TREM-1-positive cells were noted in RA synovium sections and these cells co-expressed CD14
Using a TREM-1-activating cross-linking antibody in RA synovial cultures, multiple pro-inflammatory cytokiens were induced
The average amount of soluble TREM-1 in plasma from RA patients was higher than in plasma from healthy volunteers

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