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See Latest Articlesp38 MAPK inhibition selectively mitigates inflammatory mediators and VEGF production in AF cells co-cultured with activated macrophage-like THP-1 cells
Osteoarthritis and Cartilage , 08/31/09
Kim JH et al. – Annular injury can result in macrophage infiltration, and this can cause enhanced inflammatory mediator and VEGF production by AF cells. The p38 MAPK pathway signals are responsible for much of IL–6 and PG secretion from AF cells with macrophage–like cells, suggesting that blockade of this signal may serve as a therapeutic approach to discogenic pain.
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