Rheumatology Medical News about Behcets disease;neutrophil hyperchemotaxis

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Neves FS et al. – Isolated BD neutrophils do not overexpress TLR2 neither overreact to LTA.

Methods

Expression of TLR2 and the correlate receptors CD14, CD114, CD11, and TLR4 on circulating neutrophils and monocytes of patients with active BD was assessed
Serum concentration of soluble CD14 was also measured
Neutrophil chemotactic responses from BD patients and healthy controls under LTA stimulation were assessed

Results

TLR2 expression was higher only on BD monocytes compared with healthy controls
Expression of all other receptors were similar in BD and control group
TLR2 expression on neutrophils was similar in both groups, and when stimulated with LTA, BD neutrophils showed chemotactic responses similar to the controls
Neutrophils exhibited increased chemotaxis only when incubated with BD plasma
Serum sCD14 concentration was higher in BD patients than in controls, and it was positively correlated with both CD14 expression on circulating monocytes membrane and BDCAF scores

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