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Endomorphins in rheumatoid arthritis, osteoarthritis and experimental arthritis: clinical prospects
International Journal of Clinical Rheumatology, 08/31/09
Jessop DS – Since endomorphins in their native form are susceptible to proteolytic degradation, if they are to be considered as viable therapeutic agents it is necessary to modify their structure in order to confer proteolytic resistance while maintaining bioactivity. Endomorphin analogs have only been previously tested for analgesic activity and some of these compounds have been found to be more potent than the native forms.
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