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Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis
Arthritis Research & Therapy, 08/26/09
Lundy SK et al. – Reduced numbers of splenic FasL+ CD5+ B cells correlated with increasing arthritis severity and decreased T cell death in a T cell receptor transgenic mouse model of collagen–induced arthritis. These "killer" B cells may provide a novel mechanism for inducing T cell death as a treatment for arthritis.
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