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See Latest ArticlesThe inflammatory milieu in idiopathic inflammatory myositis
Current Rheumatology Reports, 08/26/09
Reed AM et al. – The cells that are typically involved in the pathogenesis of disease are B–lymphocytes, T–lymphocytes, macrophages, dendritic cells, and natural killer cells. However, in addition to these immune cells, cells of nonimmunologic origin, such as myocytes, may be directly involved in the immune response. The local milieu also consists of distinct cytokine and chemokine profiles considered related to type 1 interferon stimulation. Tumor necrosis factor and interleukin 1 are also prominent, proinflammatory cytokines involved in the evolution of IIM.
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