Rheumatology Medical News about Etanercept, Rheumatoid arthritis, MTX

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The effect of etanercept on work productivity in patients with early active rheumatoid arthritis: Results from the COMET study
Rheumatology, 08/21/09

Anis A et al. – Study demonstrates that early treatment with etanercept (ETN) + MTX led to a significant attenuation of absenteeism among patients with early active rheumatoid arthritis (RA). These productivity gains represent benefit beyond the traditional measures of clinical and radiographic improvements.

Methods

A comparison of the impact of the combination of ETN and MTX with MTX alone on work productivity among MTX-naïve pts with active early RA over a 12-mo period
The COMET (COmbination of Methotrexate and ETanercept) trial was a 2-year double-blind randomized clinical trial
Absenteeism during the first year was measured and it included:
1. Number of missed workdays
2. Reduced working time, and
3. Number of stopped workdays
Each absenteeism measure was estimated using a mixed model; their variations estimated by bootstrapping
As a sensitivity analysis, the lost workdays due to presenteeism (reduced performance at work) was also estimated

Results

205 pts (MTX: n=100 vs ETN + MTX: n=105), who were working full time or part time at baseline and had at least one f/u observation
Compared with the MTX group, the ETN + MTX group had a max of 37 fewer missed workdays or at minimum 22 fewer missed workdays
The associated productivity gain equalled £2586 and £1555, respectively
When additionally accounting for presenteeism, the total improvement could be as high as 42 fewer lost workdays representing a productivity gain of £2968

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