Rheumatology

Your Article Summary

See Latest Articles

Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma
Arthritis Research & Therapy, 08/21/09

Kelchtermans H et al. – Study demonstrates that in the absence of IFN-gamma, IL-17 mediates its pro-inflammatory effects mainly through stimulatory effects on granulopoiesis, neutrophil infiltration and bone destruction. In vitro IFN-gamma profoundly inhibits the effector function of IL-17; this may be an additional mechanism through which IFN-gamma attenuates autoimmune diseases.

• Study analyses the mechanisms of action of IL-17 in arthritis
• Role of IFN-gamma on the effector mechanisms of IL-17 in an in vitro system was also investigated
• IFN-gammaR KO mice induced for CIA were treated with anti-IL-17 or control antibody
• The collagen type II (CII)-specific humoral and cellular autoimmune responses, myelopoiesis, osteoclastogenesis, and systemic cytokine production were determined
• Mouse embryo fibroblasts (MEF) were stimulated with IL-17, TNF-α and the expression of cytokines and chemokines were determined

• A preventive anti-IL-17 Ab treatment inhibited CIA in IFN-γR KO mice
• In the joints of anti-IL-17-treated mice, neutrophil influx and bone destruction were absent
• Treatment reduced the cellular autoimmune response as well as the splenic expansion of CD11b+ cells, and production of myelopoietic cytokines such as GM-CSF and IL-6
• IL-17 and TNF-α synergistically induced GCP-2, IL-6 and receptor activator of NFκB ligand (RANKL) in MEF
• This induction was profoundly inhibited by IFN-γ in a STAT-1 dependent way

Related Articles

See all related articles

Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs
Journal of Rheumatology, 10/05/09    Relevance Score: 77%

The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients
Rheumatology International, 10/28/09    Relevance Score: 67%

Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations
Arthritis Research & Therapy, 10/06/09    Relevance Score: 65%

Usefulness and limitations of QuantiFERON-TB Gold in Japanese rheumatoid arthritis patients: proposal to decrease the lower cutoff level for assessing latent tuberculosis infection
Modern Rheumatology, 10/19/09    Relevance Score: 64%

Monocyte derived interleukin (IL)-23 is an important determinant of synovial Il-17A expression in rheumatoid arthritis
Journal of Rheumatology, 10/05/09    Relevance Score: 64%

Today in Other Arthritis...keeping you current

Receive free subspecialty "5-minute updates" via email

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
Rheumatology, 12/20/09

A case of granulomatous mastitis with erythema nodosum and arthritis
Rheumatology International, 12/19/09

Better assessment of physical function: item improvement is neglected but essential
Arthritis Research & Therapy, 12/19/09

 See all of Other Arthritis