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See Latest ArticlesProgress in pediatric vasculitis
Current Opinion in Rheumatology, 08/18/09
O'Neil KM et al. – Review reports that international collaboration to study rare disorders such as pediatric vasculitis are demonstrating disorders of inflammatory regulation that predispose to these diseases and may point toward new treatment approaches.
Methods- Article aims to examine recent advances in the pathophysiology and therapy of pediatric vasculitis
- In the past 2 yrs significant progress is made in extending novel techniques in investigation of 2 most common pediatric vasculitis syndromes :
- Henoch-Schonlein purpura, and
- Kawasaki disease
- Study of other vasculitides, such as:
- Wegener granulomatosis
- Churg-Strauss syndrome, and
- Microscopic polyangiitis
- is impeded by the small number of pediatric pts
- Recent data suggest that disorders in the control of inflammation, such as those that underlie familial Mediterranean fever and other autoinflammatory diseases, may predispose to vasculitis
- Improved knowledge of mechanisms of disease should direct towards more targeted, effective, and tolerable therapies for children with systemic vasculitis
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