Rheumatology Medical News about Lupus, Antiphospholipid, Genetic factors

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Antiphospholipid syndrome and systemic lupus erythematosus: Are they separate entities or just clinical presentations on the same scale?
Current Opinion in Rheumatology, 08/17/09

Shoenfeld Y et al. - A multiorgan involvement that cannot be explained by the thrombophilic state per se and similar to the well known clinical manifestations in lupus is reported in patients with primary antiphospholipid syndrome (APS). Further genetic studies, will better underline the proximity between primary APS and systemic lupus erythematosus (SLE).

Methods

APS was originally recognized only as a primary APS w/o any underlying autoimmune disease in most case
This article addresses the issue if APS is somehow related to SLE as more than half of the APS cases later evolved into SLE

Results

Peculiar biological SLE markers such as an autoantibody response against chromatin antigens and complement activation have been also described in pts with primary APS
Distinct polymorphisms of common genetic factors have been associated with SLE and primary APS supporting the notion that these entities are indeed variants within a continuum of the same disease

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Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study
The Lancet Neurology, 10/16/09 Relevance Score: 88%%

A STAT4 risk allele is associated with ischemic cerebrovascular events and antiphospholipid antibodies in Systemic Lupus Erythematosus
Annals of Rheumatic Diseases, 10/23/09 Relevance Score: 87%%

Thrombin generation assay as a possible tool for assessment of reduced activity of clotting factors induced by antiphospholipid antibodies and in-vitro evaluation of treatment options
Blood Coagulation & Fibrinolysis, 11/03/09 Relevance Score: 80%%

25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus
Arthritis Care and Research, 10/01/09 Relevance Score: 80%%

Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in SLE patients
Clinical Rheumatology, 11/17/09 Relevance Score: 79%%