Rheumatology Medical News about Lupus, Interferon, Proinflammatory

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Type I interferon and lupus
Current Opinion in Rheumatology, 08/18/09

Ronnblom L et al. – Study reports that the activated type I interferons (IFN) system in lupus is critical in the etiopathogenesis of the disease and is an important therapeutic target.

Methods

Review summarizes the latest information concerning the type I IFN system in lupus

Results

Activated plasmacytoid dendritic cells are responsible for IFNα production in lupus:
- Plasmacytoid dendritic cells are triggered by interferogenic immune complexes
- The produced IFNα activates the immune system and impairs T-regulatory cell function
Autoantibodies, which can form interferogenic immune complexes, are not only present in serum of lupus pts but also in the cerebrospinal fluid of pts with neuropsychiatric manifestations
There is a strong association between risk to develop lupus and gene variants connected to the production and effects of type I IFN
Administration of monoclonal anti-IFNα Abs to lupus pts downregulates several proinflammatory pathways and reduces disease activity

<< Previous
Targeting interleukin-6 in pediatric rheumatic diseases

Next >>
B cell depletion in lupus and Sjogrens syndrome: An update

C1q inhibits immune complex-induced interferon-[alpha] production in plasmacytoid dendritic cells: A novel link between C1q deficiency and systemic lupus erythematosus pathogenesis
Arthritis & Rheumatism, 10/05/09 Relevance Score: 66%

Association of IRF5 polymorphisms with activation of the Interferon-alpha pathway
Annals of Rheumatic Diseases, 11/13/09 Relevance Score: 65%

Low prevalence of hepatitis B virus infection in patients with systemic lupus erythematosus in southern China
Rheumatology International, 10/21/09 Relevance Score: 65%

The phenotypic profile of dermatomyositis and lupus erythematosus: a comparative analysis
Journal of Cutaneous Pathology, 11/06/09 Relevance Score: 64%

Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs
Journal of Rheumatology, 10/05/09 Relevance Score: 64%