Rheumatology Medical News about T cells, B cells, Lupus

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

T-cell and B-cell signaling biomarkers and treatment targets in lupus
Current Opinion in Rheumatology, 08/17/09

Perl A et al. - Mitochondrial hyperpolarization, increased activity of mammalian target of rapamycin (mTOR) and Syk kinases, enhanced receptor recycling and Ca²⁺ flux have emerged as common T and B-cell biomarkers and targets for treatment in systemic lupus erythematosus (SLE).

Methods

A review of newly recognized genetic factors and mechanisms that underlie abnormal intracellular signal processing and intercellular communication within the immune system in SLE

Results

Activation of mTOR plays a pivotal role in abnormal activation of T and B-cells in SLE
In T-cells, increased production of nitric oxide and mitochondrial hyperpolarization were identified as metabolic checkpoints upstream of mTOR activation
mTOR controls the expression of T-cell receptor-associated signaling proteins CD4 and CD3ζ through increased expression of endosome recycling regulator HRES-1/Rab4 gene
It mediates enhanced Ca2+ fluxing and skews the expression of tyrosine kinases both in T and B-cells
Blocks the expression of Foxp3 and the expansion of regulatory T-cells
Mitochondrial hyperpolarization and the resultant ATP depletion predispose T-cells to necrosis
This leads to dendritic cell activation, antinuclear autoantibody production, and inflammation

<< Previous
Theoretical and practical basis for early aggressive therapy in...

Next >>
Genetics of systemic lupus erythematosus and Sjogrens syndrome