Rheumatology Medical News about JIA, Uveitis, E-ANA

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Biomarkers of chronic uveitis in juvenile idiopathic arthritis: Predictive value of antihistone antibodies and antinuclear antibodies
Journal of Rheumatology, 08/14/09

Nordal EB et al. – Study finds no association between ELISA for antinuclear autoantibody (E-ANA) and uveitis, and most indirect immunofluorescence (IF-ANA)-positive sera were E-ANA-negative; E-ANA is not clinically relevant in this setting and should never be used to determine frequencies of eye examinations to detect new uveitis in juvenile idiopathic arthritis (JIA). Antihistone antibodies (AHA) ≥8 U/ml, IF-ANA titer ≥320, and young age at onset of arthritis were significant predictors for development of chronic uveitis.

Methods

Aim was to investigate the predictive value of ANA tests and AHA as risk factors for development of chronic asymptomatic uveitis of insidious onset in JIA
IF-ANA using HEp-2 cells, E-ANA, and AHA were analyzed in sera of 100 children with recent-onset JIA and in 58 control sera
Clinical features, including age at onset, JIA subgroup, and presence of uveitis, were recorded

Results

E-ANA was positive in 4 of the 100 sera, and was not associated with uveitis
Chronic uveitis developed in 16 children with JIA:
- 14 of 68 positive for IF-ANA ≥80, and
- 13 of 44 positive for AHA ≥8 U/ml
IgM/IgG AHA were found in higher proportions in children with uveitis vs JIA and no uveitis or in healthy controls

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