Rheumatology Medical News about Uric acid, Metabolic syndrome, Kidney

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate
Journal of Rheumatology, 08/14/09

See LC et al. – Data demonstrate that hyperuricemia is prevalent in the Taiwan population. It is only weakly associated with renal function, but is strongly associated with metabolic syndrome with or without a low estimated glomerular filtration rate (eGFR).

Methods

Study aims to examine whether:
- SUA level is an independent risk factor for chronic kidney disease, and
- Association between SUA and metabolic syndrome is affected by kidney function
28,745 subjects (17,478 men, age 20-49 yrs) who underwent health examinations between 2000-2007
Hyperuricemia was defined as SUA level >7.7 mg/dl in men or >6.6 mg/dl in women
Kidney function was assessed by eGFR using the Modification of Diet in Renal Disease Study equation modified for Chinese subjects
Impaired renal function with low GFR was defined as eGFR <90 ml/min/1.73 m2
UA-low GFR groups were defined according to the observed combination of hyperuricemia and low GFR:
- Group A- absence of both hyperuricemia and low GFR
- Group B- presence of low GFR but no hyperuricemia
- Group C- presence of hyperuricemia but not low GFR, and
- Group D- presence of both hyperuricemia and low GFR

Results

Prevalence of hyperuricemia, metabolic syndrome, and impaired kidney function with low GFR was:
- 20.3% (27.6% in men, 8.9% in women)
- 7.6% (10.6% in men, 3.0% in women), and
- 9.9% (11.6% in men, 7.1% in women), respectively
Pearson correlation between SUA and eGFR was only -0.26 (-0.21 in men, -0.22 in women)
In men, the age-adjusted odds ratio (OR) of metabolic syndrome was 1.41 (Group B), 2.45 (Group C), and 2.58 (Group D) vs Group A
In women, the age-adjusted OR of metabolic syndrome was 0.83 (Group B), 5.47 (Group C), and 3.31 (Group D) vs Group A

<< Previous
The presence of limited joint mobility is significantly...

Next >>
Ankle disease in juvenile idiopathic arthritis: Ultrasound...