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See Latest ArticlesChanges in lipid profile between flare and remission of patients with systemic lupus erythematosus: A prospective study
Journal of Rheumatology, 08/13/09
Urquizu-padilla M et al. – Data suggest that there is a higher risk of atherosclerosis phenomena in systemic lupus erythematosus (SLE) patients during flare than during clinical remission. This might explain the propensity to develop coronary heart disease in patients with SLE.
Methods- Main objectives of this study were to:
- Determine the lipid profile of pts with SLE according to the disease activity, and
- Calculate the percentage of pts that diverged from optimal values
- Serum collected from 52 pts at flare and at remission
- SLE disease activity was measured by using SLEDAI
- Clinical and biological measures were evaluated in both situations
- After overnight fasting:
- Total cholesterol (TC)
- High-density lipoprotein cholesterol (HDLC)
- Low-density lipoprotein cholesterol (LDLC), and
- Triglyceride (TG) levels
- were analyzed
- Atherogenic ratios of TC/HDLC and LDLC/HDLC were calculated
- SLE pts had higher median TC/HDLC and LDLC/HDLC ratios at flare than during remission
- Differences persisted after adjustments based on kidney disease and treatment but not after adjusting by creatinine clearance < 60 ml/min/1.73 m2 in remission
- Variation between flare and remission of % of SLE pts with high-risk levels of lipid profile to desirable values, and vice versa, was significant for the LDLC/HDLC ratio
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