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See Latest ArticlesUsefulness of initial histological features for stratifying Sjögren's syndrome responders to mizoribine therapy
Rheumatology, 08/13/09
Nakayamada S et al. – Study demonstrates that mizoribine was clinically effective in patients with Sjögren's syndrome (SS) whose minor salivary glands had moderate cell infiltration and were free of intralobular fibrosis; drug was less effective in pts who presented intralobular fibrosis. Histological evaluation of the minor salivary glands may serve to predict the response of SS pts to mizoribine therapy.
Methods- An evaluation of the response of pts with SS to mizoribine therapy in relation to histological features of minor salivary glands
- 40 pts were treated with mizoribine (150 mg/d)
- 34 untreated pts matched for age, baseline salivary secretion, etc., served as controls
- Salivary secretion volume and serum IgG level were measured before and after 24 wks of treatment
- Each histological finding: lymphocytic infiltration, acinar atrophy and intralobular fibrosis, was graded at baseline
- Therapeutic responses were compared with the grade at 24 wks in both the groups
- An increase of the salivary secretion volume after treatment with mizoribine vs untreated control group was observed
- Effect of mizoribine on salivary secretion was more marked in pts having:
- Moderate lymphocytic infiltration
- Moderate or less severe acinar atrophy, and intralobular fibrosis
- at baseline
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