Rheumatology

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Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis
Clinical Rheumatology, 08/13/09

Ku JH et al. – Data demonstrate that synovial fluid (SF) leptin concentrations were closely related to the radiographic severity of osteoarthritis (OA), suggesting that SF leptin levels could be used as an effective marker for quantitative detection of OA.

• An investigatiom of whether SF leptin level is related to the radiographic severity of OA and its role as a quantitative marker
• SF was obtained from:
  • 42 OA pts who underwent knee surgery, and
  • 10 who had no abnormality of articular cartilage during arthroscopic examination
• The progression of OA was classified by K/L grading scale
• Concns of leptin were measured with commercial ELISA kits

• Median leptin concns in SF were higher in OA pts vs controls
• SF leptin levels showed difference according to the severity of OA
• Median SF leptin level was highest in stage IV pts which was higher vs other groups including controls
• Age showed a positive correlation with leptin concns in OA pts, but not in controls

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