Rheumatology Medical News about Ankylosing spondylitis, HLA-B, Subtypes

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HLA-B, DR and DQ antigens polymorphism in Tunisian patients with ankylosing spondylitis (a case control study)
Rheumatology International, 08/12/09

Kchir MM et al. – Study concludes that HLA-B27 subtypes of HLA-B gene predisposes to ankylosing spondylitis (AS) while B*07 and B*51 are negatively correlated with this disease.

Methods

Main objectives of this study were to:
- Assess the distribution of HLA-B genes, HLA-B27 subtypes, HLA-DRB1 and HLA-DQB1 alleles in AS pts and control subjects in the Tunisian population, and
- Compare their distribution with that found in other countries
100 consecutive pts (85 males/15 females) and 100 control individuals
HLA-B, B27 subtypes and class II (DR and DQ) typing of all subjects was performed by PCR amplification with PCR-SSP

Results

HLA-B27 was found in 62% of pts vs 3% in controls
On the other hand, B*07 and B*51 were significantly decreased in pts vs controls
8 B*27 subtypes were identified in the AS group, but the most frequent ones were B*2702 and B*2705
Among HLA-DRB1 alleles, an increase in DRB1*11 was found in pts vs controls
However, DRB1*13 had a negative association with AS
For HLA-DQB1 alleles, a positive association with DQB1*03 was observed in AS group
Multivariate analysis: DRB1*11 and DQB1*03 had no direct links with the disease, but were dependent on the presence of HLA-B27
Moreover, B*07 and B*51 seemed to have independently a negative correlation with AS, but DRB1*13 seemed to depend on B*51
Haplotypes carrying B27 were associated with AS and those carrying B*07 or B*51 were negatively correlated with the disease

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