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The relationship between disease activity and depression in patients with Behcet disease and rheumatoid arthritis
Rheumatology International, 08/12/09

Melikoglu MA et al. – Pain in rheumatoid arthritis (RA) patients, and patient’s impression of disease activity and joint involvement in Behcet disease (BD) patients were found as related factors to the depression scores. The greater ratio of BD patients with higher depression score than those in RA indicates the need for increased awareness of depressive symptoms in patients with BD.

Methods

Main objectives of this study were to:
- Determine and compare the depression levels of pts with RA and BD, and
- Investigate a possible association between disease activity and depression scores of the pts
30 RA and 30 BD pts were included
In RA patients:
- pain, morning stiffness duration, systemic involvement,
- tender–swollen joints, the physician–patient global assessments and DAS28 scores
  were determined
In pts with BD, BD Current Activity Form was assessed for disease activity
Beck depression inventory (BDI) was used for the evaluation of patient groups
BDI score above 13 was considered as cut-off point for depression
Pearson’s correlation and Mann–Whitney U tests were used for statistical analysis

Results

In RA pts, in spite of no correlation between disease activity and depression, a significant correlation between BDI scores and pain was determined
In BD group, positive correlations between BDI scores and pt’s impression of disease activity and arthralgia were determined
Number of BD pts with higher BDI scores than cut-off point was more than those in RA group

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