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See Latest ArticlesTreatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
Arthritis Research & Therapy, 08/12/09
Tat SK et al. – Study provides data on the presence and role of ephrin B2/EphB4 receptors in human chondrocytes/cartilage. Data showed that ephrin B2 treatment positively impacts the abnormal metabolism of osteoarthritic (OA) cartilage by inhibiting important catabolic factors involved in this disease at the same time as increasing anabolic activity.
Methods- An investigation of the possible implication of ephrin B2/EphB4 receptors on the catabolic/anabolic activities of human OA chondrocytes
- EphB4 receptor and ephrin B2 levels were determined by qPCR and IHC
- Effects of ephrin B2 on the expression/production of factors involved in the OA process were determined
- EphB4 receptors and ephrin B2 ligands are expressed and produced by human normal and OA chondrocytes
- Ephrin B2 protein was found at similar levels in both cartilage types
- Whereas EphB4 receptor expression and production levels were increased in OA chondrocytes/cartilage
- Ephrin B2 treatment inhibited the IL-1beta, IL-6, MMP-1, MMP-9, MMP-13, and proteinase-activated receptor-2 (PAR-2) gene expression levels
- However, MMP-2 was unaffected, and significantly increased collagen type II, a cartilage specific macromolecule
- It also inhibited the IL-1beta stimulated protein production of IL-6, MMP-1 and MMP-13
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