Rheumatology Medical News about Vitamin D, BMD, Osteoarthritis

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Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: The rotterdam study
Journal of Clinical Rheumatology (JCR), 08/06/09

Bergink AP et al. – Low dietary vitamin D intake increases the risk of progression of knee radiographic osteoarthritis (ROA), particularly in subjects with low baseline BMD. Thus, improving the vit D status in the elderly could protect against the development and worsening of knee OA, especially in those with low BMD.

Methods

Study of the association between baseline vit D status, BMD, and the development of ROA of the knee
1248 subjects (728 women) wwere drawn from the Rotterdam Study, a cohort study of the elderly
At baseline, vit D dietary intake was determined, and BMD and 25-hydroxy vitamin D levels were measured
After a mean f/u time of 6.5 yrs, incidence and progression of knee ROA was assessed

Results

Mean vit D intake was 64 IU/d and the mean 25(OH)D level 66 nmol/L
Vit D levels were associated with baseline BMD, particularly in subjects with baseline knee ROA
Progressive ROA occurred in 5.1% of the participants in the highest tertile of vit D intake against 12.6% in the lowest tertile
Both intake and levels of 25(OH)D were not related to incident ROA
In subjects with low lumbar spine BMD at baseline an increasing incidence of knee ROA with decreasing vit D intake and serum levels was observed

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