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See Latest ArticlesCatecholoestrogens: Possible role in systemic lupus erythematosus
Rheumatology, 08/05/09
Khan WA et al. – Article reviews information pertaining to the possible role of catecholoestrogens (CE) in the pathogenesis of systemic lupus erythematosus (SLE). The central hypothesis of this review is that CEs formed in different tissue undergo oxidative metabolism to produce reactive oxygen species (ROS), which could cause damage in DNA. This would probably alter its immunogenicity leading to the induction and elevated levels of SLE autoantibodies cross-reacting with native DNA.
- We must not only consider the parent oestrogens, oestradiol and oestrone, when we evaluate disease risk, but also the oestrogen metabolites should be taken in consideration
- CE metabolites, when oxidized to the electrophilic CE-Q, may react with DNA to form stable and depurinating adducts
- The 4-CE that form predominantly depurinating adducts are carcinogenic, whereas the non-carcinogenic 2-CE exclusively form stable DNA adducts
- Oxidation of CE also leads to overwhelming amount of ROS that generate:
- Extensive DNA damage
- Alter its immunogenicity
- thus leading to the induction and elevated levels of SLE autoantibodies
- Therefore, it could be possible that CE-modified bases of DNA might be one of the contributing factors towards the production of SLE autoantibodies
Wahid Ali khan, 08/05/09
| This review describes the possible role of Catecholestrogen in the aetiopathogenesis of SLE by explaining the mechanism behind the generation of autoantibodies that may unfold various aspects of SLE. |
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