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See Latest ArticlesIncreased plasma myeloperoxidase levels in systemic lupus erythematosus
Rheumatology International, 08/04/09
Telles RW et al. – Study reports that despite the lack of correlation between myeloperoxidase (MPO) plasma levels and disease activity, the higher MPO levels in patients with articular involvement suggests that MPO may play a different role in the inflammatory process of some systemic lupus erythematosus (SLE) manifestations.
Methods- Main objectives of this study were to:
- Quantify plasma MPO levels in SLE pts, and
- Evaluate a correlation between MPO levels and disease activity
- 71 female SLE pts and 70 controls; patients divided into 2 groups:
- Group I (n=48) with SLEDAI-2K score 0-5 and
- Group II (n=23) with SLEDAI-2K score ≥6
- Mann–Whitney test and Spearman rank correlation were used
- Two-sided P values <0.05 were considered significant and P values ≥0.05 and <0.08 were considered as a tendency
- Median age of pts and controls were comparable; mean disease duration was 99.2 ± 61.7 mo
- MPO levels were higher in pts than controls
- No correlation between MPO levels and SLEDAI-2k
- MPO levels were not affected by treatment with prednisone, cyclophosphamide or azathioprine
- However, a tendency of lower levels was observed among pts under antimalarial drugs
- No significant difference in MPO plasma levels between Group I and Group II
- MPO levels were higher in pts with arthritis vs those w/o arthritis
- No difference was observed among pts with and w/o other organs/systems involvement
- SLE pts presented increased MPO plasma levels than healthy controls
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Fungal Leukocytoclastic Vasculitis as a Presentation of Systemic Vasculitis in a Patient With Systemic Lupus Erythematosus
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