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See Latest ArticlesInvestigation of calcium crystals in OA knees
Rheumatology International, 08/04/09
Fuerst M et al. – The differentiation between basic calcium phosphates (BCP) and calcium pyrophosphate dihydrate (CPPD) crystals plays an important role, and the techniques presented here provide an accurate differentiation of these two types of crystals. For quantification of articular cartilage mineralization, DCR is a simple and accurate method.
Methods- Aim was to develop an effective algorithm to quantify and to identify cartilage mineralization in the experimental setting
- 4 pts with OA of the knee undergoing total knee replacement and 4 control pts
- Cartilage calcification was studied by:
- Digital contact radiography (DCR)
- Field emission scanning electron microscopy (FE-SEM) X-ray element analysis and
- Raman spectroscopy (RS)
- DCR revealed mineralization in all OA cartilage specimens
- No mineralization was observed in the control cartilage
- Patient I showed rhomboid shaped crystals with a mean Ca:P molar ratio of 1.04 indicated the presence of CPPD crystals
- Pts II, III and IV presented carbonate-substituted hydroxyapatite (HA)
- RS also showed the presence of CPPD crystals in Patient I while Patients II, III and IV revealed spectra confirming the presence of HA crystals
- In the corresponding chondrocyte cell culture analyzed with SEM, the presence of CPPD crystals in the culture of Patient I and HA crystals in the culture of Patient II, III and IV was confirmed
- No mineralization was found in the cell culture of the controls
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