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See Latest ArticlesAutoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis
Rheumatology International, 08/04/09
Okazaki S et al. – Data suggest that autoantibody against caspase-3 is generated in systemic sclerosis (SSc) and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation.
Methods- Aim was to determine the presence or levels of Abs against caspase-3 and their clinical relevance in SSc
- Anti-caspase-3 Ab was examined by ELISA
- IgG anti-caspase-3 Ab levels in SSc pts were higher vs normal controls
- SSc pts positive for IgG anti-caspase-3 Ab had:
- Longer disease duration
- More frequent presence of decreased %VC and %DLco, and
- Elevated levels of serum immunoglobulin and ESR
- IgG anti-caspase-3 Ab levels correlated positively with serum IgG levels, renal vascular resistance, and serum levels of 8-isoprostane
- Immunoblotting analysis confirmed the presence of anti-caspase-3 Ab in sera from SSc pts
- Caspase-3 enzymatic activity was inhibited by IgG isolated from SSc sera containing IgG anti-caspase-3 Ab
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